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Recombinant human CTLA-4 protein

Recombinant human CTLA-4 protein

€152.00

Excl. VAT

Item no.	NKM-ATGP3914-10ug
Manufacturer	NKMAX
Amount	10ug
Category	Oncology By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins SDS-PAGE
Type	Proteins Recombinant
Applications	SDS-PAGE
Specific against	other
Conjugate/Tag	hIgG-His-Tag
Purity	> 95% by SDS-PAGE
NCBI	NP_005205
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, ATGP3364
Available
Additional Comment Only	ATGP3364 has been replaced with a catalog number A
Antigen Species	Human
Bioactivity Comment Only	The activity is determined by the IL-2 ELISA in a using Jurkat human acute T cell leukemia cells. The ED50 range <=150ng/ml with Human B7 1/CD80.
Bioactivity Comment and Pics	Human CTLA-4 inhibits Human B7 1/CD80 induced IL-2 secretion of the Jurkat human acute T cell leukemia cells. The ED50 range <=150 ng/ml.
Bioassay Procedure	KAMHVAQ PAVVLASSRG IASFVCEYAS PGKATEVRVT VLRQADSQVT EVCAATYMMG NELTFLDDSI CTGTSSGNQV NLTIQGLRAM DTGLYICKVE LMYPPPYYLG IGNGTQIYVI DPEPCPDSD
Concentration	0.5mg/ml (determined by absorbance at 280nm)
Description	CTLA-4, also known as cytotoxic T-lymphocyte protein 4, is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. The affinity of CTLA-4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. Recombinant human CTLA-4, fused to hIgG His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Domain	36-161aa
Endotoxin	< 1 EU per 1ug of protein (determined by LAL method)
Expression System	Baculovirus
Formulation	Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Gene Category	Immunology
General References	Harper K., et al. (1991) J. Immunol. 147:1037-1044.; ; Teft WA., et al. (2006) Annu. Rev. Immunol. 24:65-97.
Molecular Weight	40.8 kDa (368aa)
Predicted nterm	Ala

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10ug

Listprice: €152.00

Price: €152.00

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Delivery expected until 9/25/2025

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