Aldolase B, Human (N-GST)

Aldolase B protein serves a pivotal role in glycolysis by catalyzing the aldol cleavage of fructose 1, 6-bisphosphate into dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate, as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. Additionally, in fructolysis, it metabolizes fructose 1-phosphate, derived from the phosphorylation of dietary fructose by fructokinase, into dihydroxyacetone phosphate and D-glyceraldehyde. Beyond its enzymatic function, Aldolase B acts as an adapter and functions as a tumor suppressor by stabilizing a ternary complex with G6PD and TP53, inhibiting G6PD activity. This regulatory mechanism helps maintain control over oxidative pentose phosphate metabolism, contributing to the overall balance of cellular metabolic pathways. Aldolase B Protein, Human (N-GST) is the recombinant human-derived Aldolase B protein, expressed by E. coli , with N-GST labeled tag. The total length of Aldolase B Protein, Human (N-GST) is 363 a.a., with molecular weight of ~60 kDa.

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Recombinant Proteins