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LAG-3 Protein, Mouse (HEK293, Fc) European Partner

€786.00
Excl. VAT
Item no. HY-P73843-100ug
Manufacturer MedChem Express
Amount 100 ug
Category
Type Proteins Recombinant
Specific against other
Purity 95.0
Smiles SGPGKELPVV WAQEGAPVHL PCSLKSPNLD PNFLRRGGVI WQHQPDSGQP TPIPALDLHQ GMPSPRQPAP GRYTVLSVAP GGLRSGRQPL HPHVQLEERG LQRGDFSLWL RPALRTDAGE YHATVRLPNR ALSCSLRLRV GQASMIASPS GVLKLSDWVL LNCSFSRPDR PVSVHWFQGQ NRVPVYNSPR HFLAETFLLL PQVSPLDSGT WGCVLTYRDG FNVSITYNLK VLGLEPVAPL TVYAAEGSRV ELPCHLPPGV GTPSLLIAKW TPPGGGPELP VAGKSGNFTL HLEAVGLAQA GTYTCSIHLQ GQQLNATVTL AVITVTPKSF GLPGSRGKLL CEVTPASGKE RFVWRPLNNL SRSCPGPVLE IQEARLLAER WQCQLYEGQR LLGATVYAAE SSSGAHSARR ISGDLKGGHL
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias LAG-3 Protein, Mouse (HEK293, Fc),Mouse,HEK293
Available
Product Description
LAG-3 (Lymphocyte activation gene 3) protein, expressed on antigen-activated T-cells, delivers inhibitory signals by binding to ligands like FGL1. FGL1 is a major ligand responsible for LAG3's T-cell inhibitory function. Upon T-cell receptor engagement, LAG3 associates with CD3-TCR, directly inhibiting T-cell activation. It may synergistically inhibit antigen-specific T-cell activation with PDCD1/PD-1, negatively regulating CD8(+) and CD4(+) T-cell proliferation, activation, effector function, and homeostasis. Constitutively expressed on some regulatory T-cells (Tregs), LAG3 aids in their suppressive function, mediating immune tolerance. Additionally, LAG3 negatively regulates plasmacytoid dendritic cell (pDCs) activation and binds to MHC class II (MHC-II), potentially acting as a ligand for MHC-II on antigen-presenting cells, promoting APC activation/maturation and driving Th1 immune responses. LAG-3 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived LAG-3 protein, expressed by HEK293, with C-hFc labeled tag. The total length of LAG-3 Protein, Mouse (HEK293, Fc) is 420 a.a., with molecular weight of ~82-96 kDa.
StorageTemperature
Stored at -20°C for 2 years
Shipping
Blue Ice
Molecular Weight
Approximately 82-96 kDa
Manufacturers Product type
Recombinant Proteins

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ug
Available: In stock
Listprice: €786.00
Price: €786.00
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