Comparison

LAG-3 Protein, Human (HEK 293, His) European Partner

€89.00
Excl. VAT
Item no. HY-P70722-10ug
Manufacturer MedChem Express
Amount 10 ug
Category
Type Cytokine
Specific against other
Purity 95.0
Smiles LQPGAEVPVV WAQEGAPAQL PCSPTIPLQD LSLLRRAGVT WQHQPDSGPP AAAPGHPLAP GPHPAAPSSW GPRPRRYTVL SVGPGGLRSG RLPLQPRVQL DERGRQRGDF SLWLRPARRA DAGEYRAAVH LRDRALSCRL RLRLGQASMT ASPPGSLRAS DWVILNCSFS RPDRPASVHW FRNRGQGRVP VRESPHHHLA ESFLFLPQVS PMDSGPWGCI LTYRDGFNVS IMYNLTVLGL EPPTPLTVYA GAGSRVGLPC RLPAGVGTRS FLTAKWTPPG GGPDLLVTGD NGDFTLRLED VSQAQAGTYT CHIHLQEQQL NATVTLAIIT VTPKSFGSPG SLGKLLCEVT PVSGQERFVW SSLDTPSQRS FSGPWLEAQE AQLLSQPWQC QLYQGERLLG AAVYFTELSS PGAQRSGRAP GALPAGHL
ECLASS 10.1 42030690
ECLASS 11.0 42030690
UNSPSC 12352202
Alias LAG-3 Protein, Human (HEK293, His),Human,HEK293
Available
Product Description
LAG-3 (Lymphocyte activation gene 3) Protein, an inhibitory receptor on antigen-activated T-cells, crucially regulates immunity. Binding to FGL1, LAG-3 delivers inhibitory signals negatively affecting CD8(+) and CD4(+) T-cell proliferation, activation, and effector function. Synergizing with PDCD1/PD-1, LAG-3 inhibits antigen-specific T-cell activation, associating with CD3-TCR at the immunological synapse. Constitutively expressed on regulatory T-cells (Tregs), LAG-3 contributes to suppressive function and immune tolerance. Additionally, LAG-3 negatively regulates plasmacytoid dendritic cell (pDCs) activation, interacting with MHC class II (MHC-II), potentially acting as both a ligand and promoter of APC activation/maturation, influencing Th1 immune response. LAG-3 Protein, Human (HEK293, His) is the recombinant human-derived LAG-3 protein, expressed by HEK293, with C-6*His labeled tag. The total length of LAG-3 Protein, Human (HEK293, His) is 428 a.a., with molecular weight of 60-80 kDa.
StorageTemperature
Stored at -80°C for 1 year
Shipping
Blue Ice
Molecular Weight
60-80 kDa
Manufacturers Product type
Recombinant Proteins

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 10 ug
Available: In stock
Listprice: €89.00
Price: €89.00
available

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