CTLA-4 Protein, Mouse (125a.a, HEK 293, Fc)

CTLA-4, a pivotal inhibitory receptor, serves as the primary negative regulator in T-cell responses within immune modulation. Its distinct property is significantly heightened affinity for B7 ligands (CD80/CD86) over CD28. The homodimeric structure, intricately linked by disulfide bonds, underscores CTLA-4's role as a molecular sentinel. Functionally, CTLA-4 avidly binds CD80/B7-1 and CD86/B7.2, competitively engaging to suppress T-cell activation and finely tune immune responses. Additionally, CTLA-4 interacts with ICOSLG, contributing to multifaceted engagement in immune checkpoint pathways. CTLA-4 Protein, Mouse (125a.a, HEK293, Fc) is the recombinant mouse-derived CTLA-4 protein, expressed by HEK293, with C-hFc labeled tag. The total length of CTLA-4 Protein, Mouse (125a.a, HEK293, Fc) is 125 a.a., with molecular weight of 50-60 kDa.

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Recombinant Proteins