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Mouse HMGB1 Protein, His Tag

Mouse HMGB1 Protein, His Tag

€2,965.00

Excl. VAT

Item no.	HM1-M52H6-1mg
Manufacturer	ACROBiosystems
Amount	1mg
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Powder
Specific against	Mouse (Murine, Mus musculus)
Conjugate/Tag	His
Purity	>90% as determined by SDS-PAGE.
Citations	(1) Wang H, et al., 1999, Science 285 (5425): 248-51. (2) Yang H, et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107 (26): 11942-7. (3) Yang H, et al., 2010, Biochim. Biophys. Acta 1799 (1-2): 149-56. (4) Fagone P, et al., 2011, Gene Ther. 18 (11): 1070-7.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	HMGB1,HMG1,HMG3,SBP-1
Available
Buffer	PBS, pH7.4
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.8 kDa. The protein migrates as 33 kDa and 35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Description	High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release. This positions HMGB1 at the intersection of sterile and infectious inflammatory responses. HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy.
Endotoxin Level	Less than 1.0 EU per ug by the LAL method.
Exp Region	Met 1 - Glu 215
Expression System	HEK293
Molecular Weight	26.8 kDa
Molecule	HMGB1
Shipping Conditions	RT
Storage	-20C

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1mg

Listprice: €2,965.00

Price: €2,965.00

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Delivery expected until 8/7/2025

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