Comparison

Mouse BAFF / TNFSF13B / CD257 Protein, Tag Free European Partner

€1,938.00
Excl. VAT
Item no. BAF-M521y-1mg
Manufacturer ACROBiosystems
Amount 1mg
Category
Type Proteins Recombinant
Format Powder
Specific against other
Conjugate/Tag Tag Free
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias TNFSF13B,BAFF,BLYS,CD257,DTL,TALL1,THANK,TNFSF20,ZTNF4,TALL-1
Available
Molecule
BAFF
Species
Mouse
Expression System
HEK293
Exp Region
Ala 127 - Leu 309
Package Size
100ug*10
Conjugate
Unconjugated
Storage
-20℃
Molecular Weight
20.9 kDa
Characteristics
This protein carries no "tag". The protein has a calculated MW of 20.9 kDa. The protein migrates as 20 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level
Less than 1.0 EU per μg by the LAL method.
Buffer
PBS, pH7.4
Description
B-cell activating factor (BAFF) is also known as tumor necrosis factor ligand superfamily member 13B , TNFSF13B, BAFF, B Lymphocyte Stimulator (BLyS) , cluster of differentiation 257 (CD257), DTL, TNF- and APOL-related leukocyte expressed ligand (TALL-1), THANK, TNFSF20, ZTNF4, and is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. It is expressed as transmembrane protein on various cell types including monocytes, dendritic cells and bone marrow stromal cells. BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R, TACI, and BCMA, all of which have differing binding affinities for it. These receptors are expressed mainly on mature B lymphocytes (TACI is also found on a subset of T-cells and BCMA on plasma cells). TACI binds worst since its affinity is higher for a protein similar to BAFF, called a proliferation-inducing ligand (APRIL). BCMA displays an intermediate binding phenotype and will work with either BAFF or APRIL to varying degrees. Signaling through BAFF-R and BCMA stimulates B lymphocytes to undergo proliferation and to counter apoptosis. All these ligands act as heterotrimers (i.e. three of the same molecule) interacting with heterotrimeric receptors, although BAFF has been known to be active as either a hetero- or homotrimer. BAFF acts as a potent B cell activator and has been shown to play an important role in the proliferation and differentiation of B cells. 
SDS-PAGE Legend
Mouse BAFF, Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Bioactivity Legend 1
Immobilized Mouse BAFF, Tag Free (Cat. No. BAF-M521y) at 2 μg/mL (100 μL/well) can bind Mouse BAFFR, Fc Tag (Cat. No. BAR-M5259) with a linear range of 0.4-3 ng/mL (QC tested).
Bioactivity Legend 2
Immobilized Mouse BAFF, Tag Free (Cat. No. BAF-M521y) at 5 μg/mL (100 μL/well) can bind Mouse BCMA, Fc Tag (Cat. No. BCA-M5258) with a linear range of 0.8-13 ng/mL (Routinely tested).

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 1mg
Available: In stock
Listprice: €1,938.00
Price: €1,938.00
available

Delivery expected until 9/4/2025 

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