Recombinant Mouse Interleukin-13/IL-13 (Ser26-Phe131,C-6His)

Mouse interleukin 13 (mIL-13) is a pleiotropic cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation & immunoglobin production. It contains a four helical bundle with two internal disulfide bonds. Mouse IL13 shares 58% sequence identity with human protein & exhibits cross-species activity. IL13 signals via receptor IL13R (type2, IL4R) & activates STAT-6. IL13 initially binds IL-13Ralpha1 with low affinity & triggers association of IL4Ralpha, generating a high affinity heterodimeric receptor IL13R & eliciting downstream signals. IL13 also binds IL-13Ralpha2 with high affinity, which plays a role in a negative feedback system of IL13 signaling. IL13 is an important mediator of allergic inflammation & disease.

Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

12, 7

Ser26-Phe131

Lyophilized protein should be stored at < -20C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20C for 3 months.