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cilomilast

cilomilast

Item no.	V0779-25mg
Manufacturer	InvivoChem LLC
CASRN	153259-65-5
Amount	25mg
Category	Food Safety Drugs Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0779CAS #:153259-65-5Purity >=98% Description: Cilomilast (also known as SB-207, 499; SB207499; trade name Ariflo) is a novel, potent and orally bioactive phosphodiesterase 4/PDE4 inhibitor with potential anti-inflammatory and immunomodulatory activity. It inhibits PDE4 with an IC50 of ca.110 nM, it has anti-inflammatory activity and low central nervous system activity. It has the potential to be used for the treatment of asthma and chronic obstructive obstructive pulmonary (COPD). Description: References: J Pharmacol Exp Ther. 1998 Nov; 287(2):705-11; Int Immunopharmacol. 2011 Jun; 11(6):732-9. References:
Molecular Weight (MW)	343.42
Formula	C20H25NO4
CAS No.	153259-65-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 69 mg/mL (200.9 mM)
	Water: < 1 mg/mL
	Ethanol: 50 mg/mL (145.6 mM)
Solubility (In vivo)	5% DMSO+95% Corn oil: 30 mg/mL
Synonyms	Cilomilast; SB 207499; SB207499; Ariflo; SB-207499; Chemical Name: cis-4-Cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexanecarboxylic acid InChi Key: CFBUZOUXXHZCFB-LDTOLXSISA-N InChi Code: InChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7, 12, 14, 16H, 2-5, 8-11H2, 1H3, (H, 22, 23)/t14-, 20+ SMILES Code: O=C([CH]1CC[C](C2=CC=C(OC)C(OC3CCCC3)=C2)(C#N)CC1)O

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25mg

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Delivery expected until 9/4/2025

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