SARS-CoV-IN-2

888958-26-7

455.72

DMSO : 19.23 mg/mL (42.20 mM; Need ultrasonic)

Anti-infection; Anti-infection; Anti-infection

SARS-CoV-IN-2 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-2 shows anti-Coronavirus activity with an EC₅₀ of 1.9 uM in Vero cells. SARS-CoV-IN-2 inhibits the 3D7 and W2 strains of P. falciparum with IC₅₀s of 21.5 and 30 nM; and IC₉₀s of 51.0 and 99.9 nM; respectively. SARS-CoV-IN-2 reduces HIV-1-induced cytopathic effect with an EC₅₀ of 2.9 uM in MT-4 cells. Antimalarial and Antiviral Activities^[1]. IC50 & Target: EC50: 1.9 uM (SARS-CoV, in Vero cells)^[1]
IC50: 21.5 nM (3D7 P. falciparum), 30 nM (W2 P. falciparum)^[1]
IC90: 51.0 nM (3D7 P. falciparum), 99.9 nM (W2 P. falciparum)^[1] In Vitro: SARS-CoV-IN-2 (Compound 3) inhibits in vitro growth of Plasmodium falciparum far better than Chloroquine (CQ) ^[1].