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Combretastatin A4

Combretastatin A4

€65.00

Excl. VAT

Item no.	HY-N2146-10mM
Manufacturer	MedChem Express
CASRN	117048-59-6
Amount	10 mM/1 mL
Category	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Adhesion Molecules Inhibitors & Compound Libraries Small Molecules By Organ Head & Neck Cancer Astrocyte Markers
Type	Inhibitors
Purity	99.76
Formula	C18H20O5
Citations	[1]Yao N, et al. Combretastatin A4 phosphate treatment induces vasculogenic mimicry formation of W256 breast carcinoma tumor in vitro and in vivo. Tumour Biol. 2015 Nov;36(11):8499-510 [2]Zhu J, et al. Co-Encapsulation of Combretastatin-A4 Phosphate and Doxorubicin in Polymersomes for Synergistic Therapy of Nasopharyngeal Epidermal Carcinoma. J Biomed Nanotechnol. 2015 Jun;11(6):997-1006. [3]Tochinai R, et al. Combretastatin A4 disodium phosphate-induced myocardial injury. J Toxicol Pathol. 2016 Jul;29(3):163-71. [4]Signoretto E, et al. Stimulation of Eryptosis by Combretastatin A4 Phosphate Disodium (CA4P). Cell Physiol Biochem. 2016;38(3):969-8
Smiles	OC1=CC(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CRC 87-09
Available
Product Description	Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	316.35
Clinical Information	Phase 2
Solubility	DMSO : 100 mg/mL (ultrasonic)
Pathway	Cell Cycle/DNA Damage; Cytoskeleton
Manufacturers Product type	Natural Products

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HY-N2146-10mM-safety-datasheet.pdf