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Doxycycline (hyclate)

Doxycycline (hyclate)

€71.00

Excl. VAT

Item no.	HY-N0565B-5g
Manufacturer	MedChem Express
CASRN	24390-14-5
Amount	5 g
Category	Oncology Food Safety Antibiotics Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis By Cell Type Blastoma Carcinoma Cell Biology Cell Status Proliferation Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer Bladder Cancer
Type	Inhibitors
Purity	99.19
Formula	C22H24N2O8.1/2C2H6O.ClH.1/2H2O
Citations	Adv Sci (Weinh). 2022 Jun 2;e2104823. Biochem Biophys Res Commun. 6 August 2022. bioRxiv. 2019 Apr. Cancer Commun (Lond). 2023 Dec 28. Cell Death Dis. 2017 Mar 23;8(3):e2702. Cell Death Dis. 2021 Apr 20;12(5):413. Cell Rep. 2021 Jun 8;35(10):109225. Cell Rep. 2021 Sep 21;36(12):109739. Cell Stem Cell. 2024 Jan 4;31(1):52-70.e8. Elife. 2021 Oct 27;10:e65759. Food Funct. 16th November 2021. Institute of Pharmacology and Toxicology University of Zürich. 2019 Nov. J Biol Chem. 2022 Aug 12;102374. J Biol Chem. 2023 Mar 17;104621. J Genet Genomics. 2020 Nov 20;47(11):705-712. Mol Cancer. 2020 Sep 9;19(1):139. Nat Commun. 2023 Dec 20;14(1):8461. Patent. US 2019/0365645 A1. Research Square Print. 2022 May. Research Square Print. 2023 Mar 1. STAR Protoc. 2021 Nov 5;2(4):100881. STAR Protoc. 2021, 100548. STAR Protoc. 2022 Apr 13;3(2):101296. STAR Protoc. 2023 Feb 3;4(1):102092. Theranostics. 2022 Jan 1;12(3):1187-1203. Adv Sci (Weinh). 2021 Mar 15;8(10):2004344. Ann Lab Med. 2021 May 1;41(3):293-301. Biochem Biophys Res Commun. 30 July 2022. Biomed Pharmacother. 2023 Jun 8;164:114998. bioRxiv. 2023 Jun 14. bioRxiv. 2023 Mar 31. Cancer Biol Ther. 2022 Dec 31;23(1):328-335. Cancer Res. 2023 Jul 18;CAN-23-0015. Cell Commun Signal. 2022 Apr 12;20(1):52. Cell Death Differ. 2023 Jun 15. Cell Death Dis. 2020 May 7;11(5):331. Cell Death Dis. 2022 Feb 10;13(2):138. Cell Prolif. 2023 Aug 17;e13534. Clin Exp Pharmacol Physiol. 2023 Apr 22. FASEB J. 2020 Dec;34(12):16716-16735. Front Cell Infect Microbiol. 28 April 2021. Int J Mol Med. 2020 Apr;45(4):1187-1194. iScience. 2023 Mar. Katedra farmakologie a toxikologie. 2020 Jul. Mol Cancer. 2020 Mar 30;19(1):68. Molecules. 2023 Jul 26, 28(15), 5668. Nat Microbiol. 2023 Mar;8(3):410-423. NPJ Parkinsons Dis. 2022 Aug 6;8(1):100. Oncogene. 2023 Dec 15. Redox Biol. 2023 Mar 21;62:102686. Research Square Preprint. 2020 Jun. Research Square Preprint. 2023 Jul 11. Sci Adv. 2022 Jan 28;8(4):eabl5220. Theranostics. 2022 Mar 28;12(7):3131-3149. Virol Sin. 2022 May 12;S1995-820X(22)00081-5. Water Res. 2023 May 21, 120110. Cancer Lett. 2016 Jun 28;376(1):188-96. Cell Death Differ. 2019 Nov;26(11):2400-2415. Cell. 2023 Feb 2;186(3):591-606.e23. [1]Eusebio Manchado, et al. A combinatorial strategy for treating KRAS-mutant lung cancer. Nature. 2016 Jun 30;534(7609):647-51. [2]Wilfried Briest, et al. Doxycycline ameliorates the susceptibility to aortic lesions in a mouse model for the vascular type of Ehlers-Danlos syndrome. J Pharmacol Exp Ther. 2011 Jun;337(3):621-7. [3]Anna-Luisa Luger, et al. Doxycycline Impairs Mitochondrial Function and Protects Human Glioma Cells from Hypoxia-Induced Cell Death: Implications of Using Tet-Inducible Systems. Int J Mol Sci. 2018 May 17;19(5):1504. [4]Ethan Ahler, et al. Doxycycline alters metabolism and proliferation of human cell lines. PLoS One. 2013 May 31;8(5):e64561. [5]Le Zhang, et al. Doxycycline inhibits the cancer stem cell phenotype and epithelial-to-mesenchymal transition in breast cancer. Cell Cycle. 2017 Apr 18;16(8):737-745.
Smiles	O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])[C@@H](O)[C@]3([H])[C@@H](C)C4=C(C(C3=C(O)[C@@]21O)=O)C(O)=CC=C4)N.Cl.[0.5H2O].[0.5C2H6O]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Doxycycline (hydrochloride hemiethanolate hemihydrate); WC2031
Available
Product Description	Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity[1][2][3][4][5].
StorageTemperature	4°C (Powder, sealed storage, away from moisture and light)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
Molecular Weight	512.94
Clinical Information	Launched
Solubility	DMSO : 240 mg/mL (ultrasonic)\|H2O : 125 mg/mL (ultrasonic)
Isoform	Tetracycline
Pathway	Anti-infection; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-N0565B-5g-safety-datasheet.pdf