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alpha-Mangostin

alpha-Mangostin

€374.00

Excl. VAT

Item no.	HY-N0328-100mg
Manufacturer	MedChem Express
CASRN	01.11.6147
Amount	100 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Bladder Cancer Brain Cancer
Type	Inhibitors
Purity	99.64
Formula	C24H26O6
Citations	[1]Kim HJ, et al. Discovery of α-mangostin as a novel competitive inhibitor against mutant isocitrate dehydrogenase-1. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5625-31. [2]Lee HN, et al. Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.) in YD-15 tongue mucoepidermoid carcinoma cells. Int J Mol Med. 2016 Apr;37(4):939-48.
Smiles	O=C1C2=C(OC3=C1C(C/C=C(C)\C)=C(OC)C(O)=C3)C=C(O)C(C/C=C(C)\C)=C2O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	α-Mangostin
Available
Product Description	alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	410.46
Clinical Information	No Development Reported
Solubility	DMSO : 110 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL (ultrasonic)
Pathway	Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Manufacturers Product type	Natural Products

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HY-N0328-100mg-safety-datasheet.pdf