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Corosolic acid

Corosolic acid

€49.00

Excl. VAT

Item no.	HY-N0280-5mg
Manufacturer	MedChem Express
CASRN	4547-24-4
Amount	5 mg
Category	Oncology Neuroscience Neuroinflammation Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Colorectal Cancer Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	98.0
Formula	C30H48O4
Citations	[1]Ma B, et al. Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3. J Exp Clin Cancer Res. 2018 Sep 3;37(1):210. [2]Zhang BY, et al. Corosolic acid inhibits colorectal cancer cells growth as a novel HER2/HER3 heterodimerization inhibitor. Br J Pharmacol. 2021 Mar;178(6):1475-1491. [3]Yang J, et al. Corosolic acid inhibits adipose tissue inflammation and ameliorates insulin resistance via AMPK activation in high-fat fed mice. Phytomedicine. 2016 Feb 15;23(2):181-90. [4]Ahn KS, et al. Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent. Planta Med. 1998 Jun;64(5):468-70. [5]LI Biao, et al. Mechanism of antitumor action of corosolic acid. China Journal of Modern Medicine, 2015-08 [6]Ki Hyun Yoo, et al. Corosolic Acid Exhibits Anti-angiogenic and Anti-lymphangiogenic Effects on In Vitro Endothelial Cells and on an In Vivo CT-26 Colon Carcinoma Animal Model. Phytotherapy Research, 2015 , 29 (5): 14–723
Smiles	O[C@H]1[C@H](O)C(C)(C)[C@@](CC[C@]2(C)[C@]3([H])CC=C4[C@@]2(C)CC[C@]5(C(O)=O)[C@@]4([H])[C@@H](C)[C@H](C)CC5)([H])[C@]3(C)C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Colosolic acid
Available
Product Description	Corosolic acid (Colosolic acid) isolated from the fruit of Cratoegus pinnatifida var. psilosa, was reported to have anticancer activity. Corosolic acid induces cancer cell apoptosis[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	472.70
Clinical Information	No Development Reported
Solubility	DMSO : 25 mg/mL (ultrasonic)
Pathway	Apoptosis; Autophagy; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Natural Products

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HY-N0280-5mg-safety-datasheet.pdf