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Terfenadine

Terfenadine

€72.00

Excl. VAT

Item no.	HY-B1193-10mM
Manufacturer	MedChem Express
CASRN	50679-08-8
Amount	10 mM/1 mL
Category	Cardiovascular Research Ischemia & Reperfusion Injury Hypertension Inhibitors & Compound Libraries Small Molecules Arrhythmias
Type	Inhibitors
Specific against	other
Purity	99.93
Formula	C32H41NO2
Citations	[1]Kamiya K, et al. Molecular determinants of hERG channel block by terfenadine and cisapride. J Pharmacol Sci. 2008 Nov;108(3):301-307. [2]Nicolau-Galmés F, et al. Terfenadine induces apoptosis and autophagy in melanoma cells through ROS-dependent and -independent mechanisms. Apoptosis. 2011 Dec;16(12):1253-67. [3]An L, et al. Terfenadine combined with epirubicin impedes the chemo-resistant human non-small cell lung cancer both in vitro and in vivo through EMT and Notch reversal. Pharmacol Res. 2017 Oct;124:105-115.
Smiles	OC(C1=CC=C(C(C)(C)C)C=C1)CCCN2CCC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)CC2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	(±)-Terfenadine; MDL-991
Available
Product Description	Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM[1]. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9[2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	471.67
Clinical Information	Launched
Solubility	DMSO : ≥ 50 mg/mL\|H2O : 0.67 mg/mL (ultrasonic)
Isoform	Caspase 2; Caspase 4; Caspase 9; H1 Receptor
Pathway	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-B1193-10mM-safety-datasheet.pdf