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Amlexanox

Amlexanox

Item no.	HY-B0713-10mM
Manufacturer	MedChem Express
CASRN	68302-57-8
Amount	10 mM/1 mL
Category	Oncology Food Safety Histamines Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite Molecular Targets for Neuroscience Targets for Rodent Neurosciences Inhibitors & Compound Libraries Small Molecules By Organ Lymphatic System Cancer Bone Cancer Neuronal Cell Markers Astrocyte Markers
Type	Inhibitors
Purity	99.88
Formula	C16H14N2O4
Citations	[1]Bell, J. AmLexanox for the treatment of recurrent aphthous ulcers. Clin Drug Investig, 2005. 25(9): p. 555-66. [2]Reilly SM, et al. An inhibitor of the protein kinases TBK1 and IKK-e improves obesity-related metabolic dysfunctions in mice. Nat Med. 2013 Mar;19(3):313-21. [3]Zhang Y, et al. AmLexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss. Sci Rep. 2015 Sep 4;5:13575.
Smiles	O=C(C1=C(N)N=C2C(C(C3=CC(C(C)C)=CC=C3O2)=O)=C1)O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AA673; Amoxanox; CHX3673
Available
Product Description	Amlexanox (AA673; Amoxanox; CHX3673) is a specific inhibitor of IKKε and TBK1, and inhibits the IKKε and TBK1 activity determined by MBP phosphorylation with an IC50 of approximately 1-2 μM.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-sugar/lipid metabolism
Molecular Weight	298.29
Clinical Information	Launched
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : 1 mg/mL (ultrasonic; warming; heat to 80°C)
Isoform	IKKε; TBK1
Pathway	NF-κB
Manufacturers Product type	Reference compound

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HY-B0713-10mM-safety-datasheet.pdf