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Indinavir sulfate

Indinavir sulfate

€65.00

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Item no.	HY-B0689A-10mM
Manufacturer	MedChem Express
CASRN	157810-81-6
Amount	10 mM/1 mL
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.96
Formula	C36H49N5O8S
Citations	bioRxiv. 2020 Apr. Front Pharmacol. 2021 Apr 12;12:634097. Int J Antimicrob Agents. 2019 Dec;54(6):814-819. Signal Transduct Target Ther. 2021 May 29;6(1):212. Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00872-20. Antiviral Res. 2022 Nov 10;105463. Nat Commun. 2020 Sep 4;11(1):4417. Toxicol In Vitro. 2023 Sep 1;105689. [1]Chavan S, et al. The HIV protease inhibitor Indinavir inhibits cell-cycle progression in vitro in lymphocytes of HIV-infected and uninfected individuals. Blood. 2001 Jul 15;98(2):383-9. [2]Esposito V, et al. Evaluation of antitumoral properties of the protease inhibitor indinavir in a murine model of hepatocarcinoma. Clin Cancer Res. 2006 Apr 15;12(8):2634-9. [3]Liu F, et al. Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J Mol Biol. 2005 Dec 9;354(4):789-800. [4]Hall DC Jr, et al. A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease. Travel Med Infect Dis. 2020 May-Jun;35:101646.
Smiles	O=C([C@@H](C[C@H](O)CN(CCN(CC1=CN=CC=C1)C2)[C@@H]2C(NC(C)(C)C)=O)CC3=CC=CC=C3)N[C@H]4C(C=CC=C5)=C5C[C@H]4O.O=S(O)(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	MK-639; L735524
Available
Product Description	Indinavir sulfate (MK-639) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir sulfate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir sulfate is also a SARS-CoV 3CLpro inhibitor[1][2][3][4].
StorageTemperature	-20°C (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	COVID-19-anti-virus
Molecular Weight	711.87
Clinical Information	Launched
Solubility	DMSO : ≥ 100 mg/mL\|H2O : 50 mg/mL (ultrasonic)
Isoform	HIV-1; MMP-2
Pathway	Anti-infection; Apoptosis; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-B0689A-10mM-safety-datasheet.pdf