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Propranolol hydrochloride

Propranolol hydrochloride

€78.00

Excl. VAT

Item no.	HY-B0573-100mg
Manufacturer	MedChem Express
CASRN	318-98-9
Amount	100 mg
Category	Metabolism Diabetes Glucose Homeostasis Cardiovascular Research Myocardial Infarction Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.97
Formula	C16H22ClNO2
Citations	Behav Brain Res. 28 October 2021, 113642. Biochem Biophys Res Commun. 2023 Mar 21;657:69-79. BMC Pulm Med. 2021 Jun 5;21(1):189. Chemosphere. 2019 Jun;225:378-387. J Endocrinol. 2020 Mar;244(3):459-471. Psychopharmacology. 2023 Jun 17. Am J Pathol. 2023 Apr 21;S0002-9440(23)00132-3. Environ Toxicol. 2023 Dec 2. Exp Neurol. 2023 Apr 19;114418. iScience. 2023 Jul 19. J Chromatogr B. 2023 Jun 20, 123804. J Pharmaceut Biomed. 2020, 113870. Nat Commun. 2023 May 2;14(1):2523. Pharmacol Res Perspect. 2020 Apr;8(2):e00575. Pharmacol Res Perspect. 2021 Oct;9(5):e00879. Research Square Print. December 21st, 2022. Sci Signal. 2020 Nov 24;13(659):eaax0273. [1]Munabi NC, et al. Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation. Stem Cells Transl Med. 2016 Jan;5(1):45-55. [2]Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70(5):1575-84. Epub 2006 Aug 1 [3]Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69(4):669-73. [4]Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338.
Smiles	OC(CNC(C)C)COC1=CC=CC2=CC=CC=C12.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	318-98-9
Available
Product Description	Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
Molecular Weight	295.80
Clinical Information	Launched
Solubility	DMSO : ≥ 150 mg/mL\|H2O : 33.33 mg/mL (ultrasonic)
Isoform	β adrenergic receptor
Pathway	Anti-infection; GPCR/G Protein; Neuronal Signaling
Manufacturers Product type	Natural Products

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-B0573-100mg-safety-datasheet.pdf