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Carbimazole

Carbimazole

Item no.	HY-B0558-1g
Manufacturer	MedChem Express
CASRN	22232-54-8
Amount	1 g
Category	Oncology Food Safety Drugs Inhibitors & Compound Libraries Small Molecules By Organ Thyroid Cancer
Type	Inhibitors
Purity	99.92
Formula	C7H10N2O2S
Citations	[1]Nakashima, T. and A. Taurog, Rapid conversion of carbimazole to methimazole in serum; evidence for an enzymatic mechanism. Clin Endocrinol (Oxf), 1979. 10(6): p. 637-48. [2]Lehane C, et al. Carbimazole is an inhibitor of protein synthesis and protects from neuronal hypoxic damage in vitro. J Pharmacol Exp Ther. 2013 Dec;347(3):781-93. [3]H. Saeed, et al. Effects of Dose Level of Anti-thyroid Drug Carbimazole on Thermoregulation and Blood Constituents in Male Rabbits (Oryctolagus cuniculus). Advances in Research, 2014, 2(3), 129–144.
Smiles	O=C(N1C=CN(C)C1=S)OCC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	22232-54-8
Available
Product Description	Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Molecular Weight	186.23
Clinical Information	Launched
Solubility	DMSO : 100 mg/mL (ultrasonic)
Pathway	MAPK/ERK Pathway
Manufacturers Product type	Reference compound

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HY-B0558-1g-safety-datasheet.pdf