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Nateglinide

Nateglinide

€49.00

Excl. VAT

Item no.	HY-B0422-10mg
Manufacturer	MedChem Express
CASRN	105816-04-4
Amount	10 mg
Category	Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Cardiovascular Research Ischemia & Reperfusion Injury Hypertension Inhibitors & Compound Libraries Small Molecules Arrhythmias
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.51
Formula	C19H27NO3
Citations	[1]Christopher J. Dunn, et al. Nateglinide. OFILE Drugs 2000 Sep: 60 (3): 6. [2]Shiling Hu, et al. Interaction of nateglinide with KATP channel in h-cells underlies its unique insulinotropic action. European Journal of Pharmacology. 442 (2002) 163-171. [3]Jian Luo, et al. Evaluating insulin secretagogues in a humanized mouse model with functional human islets. Metabolism. 2013 Jan;62(1):90-9. [4]Duffy NA, et al. Effects of antidiabetic drugs on dipeptidyl peptidase IV activity: nateglinide is an inhibitor of DPP IV and augments the antidiabetic activity of glucagon-like peptide-1. Eur J Pharmacol. 2007 Jul 30;568(1-3):278-86.
Smiles	O=C(O)[C@@H](CC1=CC=CC=C1)NC([C@H]2CC[C@H](C(C)C)CC2)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	A4166; Senaglinide
Available
Product Description	Nateglinide, a D-phenylalanine derivative, is an orally active and short-acting insulinotropic agent and a DPP IV inhibitor. Nateglinide inhibits ATP-sensitive K+ channels in pancreatic β-cells. Nateglinide is used for the treatment of type 2 (non-insulin-dependent) diabetes mellitus[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
Molecular Weight	317.42
Clinical Information	Launched
Solubility	DMSO : 100 mg/mL (ultrasonic)
Isoform	DPP-4
Pathway	Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-B0422-10mg-safety-datasheet.pdf