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Nicorandil

Nicorandil

€66.00

Excl. VAT

Item no.	HY-B0341-10mM
Manufacturer	MedChem Express
CASRN	65141-46-0
Amount	10 mM/1 mL
Category	Oncology Cardiovascular Research Ischemia & Reperfusion Injury Heart Failure Myocardial Infarction Hypertension Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer
Type	Inhibitors
Purity	99.91
Formula	C8H9N3O4
Citations	[1]Mitsuhiko Yamada, et al. The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels. Mol Pharmacol. 2004 May;65(5):1198-207. [2]Nakae, I., et al., Effects of intravenous nicorandil on coronary circulation in humans: plasma concentration and action mechanism. J Cardiovasc Pharmacol, 2000. 35(6): p. 919-25. [3]Sauzeau, V., et al., Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle. J Biol Chem, 2000. 275(28): p. 21722-9.
Smiles	O=C(C1=CC=CN=C1)NCCO[N+]([O-])=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	SG-75
Available
Product Description	Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
Molecular Weight	211.17
Clinical Information	Launched
Solubility	DMSO : ≥ 33 mg/mL\|H2O : ≥ 20 mg/mL
Pathway	Membrane Transporter/Ion Channel
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-B0341-10mM-safety-datasheet.pdf