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Diphenhydramine hydrochloride

Diphenhydramine hydrochloride

€54.00

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Item no.	HY-B0303A-10mM
Manufacturer	MedChem Express
CASRN	147-24-0
Amount	10 mM/1 mL
Category	Food Safety Histamines Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Purity	99.90
Formula	C17H22ClNO
Citations	[1]Simons FE. H1-receptor antagonists. Comparative tolerability and safety. Drug Saf. 1994;10(5):350-380. [2]Sadiq MW, et al. Diphenhydramine active uptake at the blood-brain barrier and its interaction with oxycodone in vitro and in vivo. J Pharm Sci. 2011;100(9):3912-3923. [3]Hamano H, et al. Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity. Kidney Int. 2021 Apr;99(4):885-899. [4]Jangi SM, et al. Apoptosis of human T-cell acute lymphoblastic leukemia cells by diphenhydramine, an H1 histamine receptor antagonist. Oncol Res. 2004;14(7-8):363-72. [5]Zhang R, Chen M, Yu L, et al. Anticancer activity of diphenhydramine against pancreatic cancer by stimulating cell cycle arrest, apoptosis, and modulation of PI3K/Akt/mTOR pathway[J]. Cell proliferation, 2021, 69: 5.
Smiles	CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	147-24-0
Available
Product Description	Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB)[1][2].
StorageTemperature	4°C (Powder, sealed storage, away from moisture and light)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
Molecular Weight	291.82
Clinical Information	Launched
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : 100 mg/mL (ultrasonic)
Isoform	H1 Receptor
Pathway	Anti-infection; Apoptosis; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-B0303A-10mM-safety-datasheet.pdf