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Amiloride hydrochloride dihydrate

Amiloride hydrochloride dihydrate

€72.00

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Item no.	HY-B0285B-10mM
Manufacturer	MedChem Express
CASRN	17440-83-4
Amount	10 mM/1 mL
Category	Food Safety Proteins Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Purity	99.85
Formula	C6H13Cl2N7O3
Citations	Transl Res. 2023 Sep 5;S1931-5244(23)00143-3. ACS Nano. 2023 Apr 14. Adv Sci (Weinh). 2023 Dec 14:e2307880. Am J Transl Res. 2021 Jul 15;13(7):7538-7555. Cell Commun Signal. 2023 May 4;21(1):99. Cell Metab. 2022 Dec 6;34(12):2018-2035.e8. Cell Physiol Biochem. 2018;51(6):2564-2574. Commun Biol. 2022 Nov 14;5(1):1248. Environ Sci Technol. 2021 Feb 11. J Am Chem Soc. 2018 Dec 12;140(49):17234-17240. J Nanobiotechnology. 2020 Jan 31;18(1):26. J Pharmaceut Biomed. 2020, 113870. Microb Pathog. 2019 Jul 18:103638. Nanotechnology. 2018 Feb 23;29(8):085101. Small Methods. 2020 Dec 18. Theranostics. 2019 May 31;9(13):3732-3753. Biomaterials. 2022 May;284:121529. Br J Pharmacol. 2020 Aug;177(15):3473-3488. Cell Rep. 2022 May 31;39(9):110880. Int J Biol Macromol. 14 March 2022. iScience. 19 October 2022, 105403. J Ethnopharmacol. 2022 Mar 5;115171. J Neuroinflammation. 2022 Feb 22;19(1):53. Sci Total Environ. 2021, 146523. Theranostics. 2020 May 17;10(15):6581-6598. [1]Giamarchi A, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 7;29(7):1176-91. [2]Miller RL, et al. Blockade of ENaCs by amiloride induces c-Fos activation of the area postrema. Brain Res. 2015 Mar 19;1601:40-51. [3]Xu LB, et al. Amiloride, a urokinase-type plasminogen activator receptor (uTPA) inhibitor, reduces proteinurea in podocytes. Genet Mol Res. 2015 Aug 14;14(3):9518-29.
Smiles	O=C(C1=NC(Cl)=C(N)N=C1N)NC(N)=N.[H]Cl.O.O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	MK-870 hydrochloride dihydrate
Available
Product Description	Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2[3]) channel.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neurodegeneration
Molecular Weight	302.12
Clinical Information	Launched
Solubility	DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : 2 mg/mL (ultrasonic)
Pathway	Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-B0285B-10mM-safety-datasheet.pdf