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Carmofur

Carmofur

€59.00

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Item no.	HY-B0182-100mg
Manufacturer	MedChem Express
CASRN	61422-45-5
Amount	100 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.95
Formula	C11H16FN3O3
Citations	[1]Realini N, et al. Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity. Sci Rep. 2013;3:1035. [2]Jin Z, et al. Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur. Nat Struct Mol Biol. 2020;27(6):529-532.
Smiles	O=C(N(C(N1)=O)C=C(F)C1=O)NCCCCCC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	HCFU
Available
Product Description	Carmofur (HCFU), a derivative of 5-Fluorouracil, is an antineoplastic agent. Carmofur is an inhibitor of acid ceramidase with an IC50 of 79 nM for the rat enzyme. Carmofur inhibits the SARS-CoV-2 main protease (Mpro). Carmofur Inhibits SARS-CoV-2 in Vero E6 cell with an EC50 of 24.3 μM[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	257.26
Clinical Information	Launched
Solubility	DMSO : ≥ 100 mg/mL\|H2O : 0.67 mg/mL (ultrasonic)
Pathway	Anti-infection; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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HY-B0182-100mg-safety-datasheet.pdf