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Carvedilol

Carvedilol

€118.00

Excl. VAT

Item no.	HY-B0006-500mg
Manufacturer	MedChem Express
CASRN	72956-09-3
Amount	500 mg
Category	Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Cardiovascular Research Heart Failure Myocardial Infarction Hypertension Inhibitors & Compound Libraries Small Molecules Arrhythmias
Type	Inhibitors
Purity	99.89
Formula	C24H26N2O4
Citations	[1]Wong WT, et al. Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome. Front Immunol. 2018 Aug 22;9:1920. [2]Eggertsen R, et al. Acute haemodynamic effects of carvedilol (BM 14190), a new combined beta-adrenoceptor blocker and precapillary vasodilating agent, in hypertensive patients. Eur J Clin Pharmacol. 1984;27(1):19-22. [3]Feuerstein GZ, et al. Myocardial protection by the novel vasodilating beta-blocker, carvedilol: potential relevance of anti-oxidant activity. J Hypertens Suppl. 1993 Jun;11(4):S41-8.
Smiles	OC(CNCCOC1=CC=CC=C1OC)COC2=CC=CC(N3)=C2C4=C3C=CC=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BM 14190
Available
Product Description	Carvedilol (BM 14190) is a non-selective β/α-1 blocker[1]. Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC50 of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure[2]. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome[3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	406.47
Clinical Information	Launched
Solubility	DMSO : 100 mg/mL (ultrasonic)
Pathway	Anti-infection; Autophagy; GPCR/G Protein; Neuronal Signaling
Manufacturers Product type	Reference compound

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HY-B0006-500mg-safety-datasheet.pdf