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Bazedoxifene acetate

Bazedoxifene acetate

€49.00

Excl. VAT

Item no.	HY-A0036-5mg
Manufacturer	MedChem Express
CASRN	198481-33-3
Amount	5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Breast Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.98
Formula	C32H38N2O5
Citations	J Med Chem. 2020 Oct 8;63(19):11085-11099. mSphere. 2020 Apr 8;5(2):e00124-20. Breast Cancer Res Treat. 2020 Jan;179(1):67-77. Eur J Pharmacol. 2023 Mar 24;947:175681. Free Radic Biol Med. 2023 Aug, 139, 108897. Glia. 2022 Sep 12. Gynecol Oncol. 2019 Jul;154(1):199-206. J Cell Biochem. 2023 Aug 11. Research Square Preprint. 2020 Nov 4;rs.3.rs-100914. Research Square Preprint. 2022 Jul. [1]Barry S Komm, et al. Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity. Endocrinology. 2005 Sep;146(9):3999-4008. [2]Xiaojuan Wu, et al. Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy. Mol Cancer Ther. 2016 Nov; 15(11): 2609–2619.
Smiles	CC1=C(C2=CC=C(O)C=C2)N(CC3=CC=C(OCCN4CCCCCC4)C=C3)C5=CC=C(O)C=C51.CC(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	TSE-424 (acetate)
Available
Product Description	Bazedoxifene acetate (TSE-424 acetate) is an oral, nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene acetate can be used for the research of osteoporosis. Bazedoxifene acetate also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[1][2].
StorageTemperature	4°C (Powder, sealed storage, away from moisture and light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	530.65
Clinical Information	Launched
Solubility	DMSO : ≥ 100 mg/mL\|H2O : 1 mg/mL (ultrasonic)
Pathway	Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-A0036-5mg-safety-datasheet.pdf