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BMS 299897

BMS 299897

€119.00

Excl. VAT

Item no.	HY-50883-10mg
Manufacturer	MedChem Express
CASRN	290315-45-6
Amount	10 mg
Category	Food Safety Antibiotics Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Inhibitors & Compound Libraries Small Molecules Neuronal Cell Markers
Type	Inhibitors
Specific against	other
Purity	99.24
Formula	C24H21ClF3NO4S
Citations	[1]Meunier J, et al. The γ-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1-42 seeding and short-term memory deficits in the Aβ25-35 mouse model of Alzheimer's d [2]Weissmiller AM, et al. A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015 Feb 24;10(2):e0118379.
Smiles	FC1=CC=C(F)C(N([C@@H](C2=C(CCCC(O)=O)C=C(F)C=C2)C)S(C3=CC=C(Cl)C=C3)(=O)=O)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	290315-45-6
Available
Product Description	BMS 299897 is a sulfonamide γ-secretase inhibitor with an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neurodegeneration
Molecular Weight	511.94
Clinical Information	No Development Reported
Solubility	DMSO : ≥ 30 mg/mL
Pathway	Neuronal Signaling; Stem Cell/Wnt
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-50883-10mg-safety-datasheet.pdf