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STO-609

STO-609

€1,131.00

Excl. VAT

Item no.	HY-19805-25mg
Manufacturer	MedChem Express
CASRN	52029-86-4
Amount	25 mg
Category	Oncology Neuroscience Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules By Organ Brain Cancer Nervous System Cancer
Type	Inhibitors
Purity	98.13
Formula	C19H10N2O3
Citations	[1]Tokumitsu H, et al. STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J Biol Chem. 2002 May 3;277(18):15813-8. [2]Kukimoto-Niino M, et al. Crystal structure of the Ca<sup>2+</sup>/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609. J Biol Chem. 2011 Jun 24;286(25):22570-9.
Smiles	O=C(C1=C2C3=C(C4=NC5=CC=CC=C5N4C(C3=CC=C2)=O)C=C1)O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	52029-86-4
Available
Product Description	STO-609 is a selective and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK), with Ki values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC50 ~0.02 g/ml.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-sugar/lipid metabolism
Molecular Weight	314.29
Clinical Information	No Development Reported
Solubility	\|DMF : 5.56 mg/mL (ultrasonic)\|H2O : 0.1 mg/mL (ultrasonic)
Pathway	Autophagy; Epigenetics; Neuronal Signaling; PI3K/Akt/mTOR
Manufacturers Product type	Reference compound

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HY-19805-25mg-safety-datasheet.pdf