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NMS-P118

NMS-P118

€248.00

Excl. VAT

Item no.	HY-18954-10mg
Manufacturer	MedChem Express
CASRN	1262417-51-5
Amount	10 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Breast Cancer Bone Cancer
Type	Inhibitors
Specific against	other
Purity	99.78
Formula	C20H24F3N3O2
Citations	[1]Papeo G, et al. Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy. J Med Chem. 2015 Sep 10;58(17):6875-98.
Smiles	FC(CC1)(F)CCC1N(CC2)CCC2N(C3=O)CC4=C3C(C(N)=O)=CC(F)=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1262417-51-5
Available
Product Description	NMS-P118 is a potent, orally available, and highly selective PARP-1 Inhibitor for cancer therapy.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	395.42
Clinical Information	No Development Reported
Solubility	DMSO : 16 mg/mL (ultrasonic; warming)
Isoform	PARP1; PARP2
Pathway	Cell Cycle/DNA Damage; Epigenetics
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-18954-10mg-safety-datasheet.pdf