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Ro 48-8071 fumarate

Ro 48-8071 fumarate

€87.00

Excl. VAT

Item no.	HY-18630A-10mg
Manufacturer	MedChem Express
CASRN	189197-69-1
Amount	10 mg
Category	Food Safety Hormones Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.42
Formula	C27H31BrFNO6
Citations	Cell Death Dis. 2021 May 13;12(5):482. Cell Rep. 2022 Dec 13;41(11):111827. ImmunoMedicine. 2022 Dec. Mol Med Rep. 2021 Dec;24(6):828. ACS Synth Biol. 2023 Feb 28. Cancer Cell. 2023 May 23;S1535-6108(23)00142-3. Mol Cell. 2021 Jul 1;81(13):2736-2751.e8. Nat Commun. 2023 Jul 17;14(1):4267. Oncotarget. 2017 Feb 28;8(9):14860-14875. Sci China Life Sci. 2021 May 27;1-21. [1]Liang Y, et al. Cholesterol biosynthesis inhibitors as potent novel anti-cancer agents: suppression of hormone-dependent breast cancer by the oxidosqualene cyclase inhibitor RO 48-8071. Breast Cancer Res Treat. 2014 Jul;146(1):51-62. [2]Morand OH, et al. Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. J Lipid Res. 1997 Feb;38(2):373-90. [3]Liang Y, et al. Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells. Onco Targets Ther. 2016 May 30;9:3223-32 [4]Chuang JC, et al. Sustained and selective suppression of intestinal cholesterol synthesis by Ro 48-8071, an inhibitor of 2,3-oxidosqualene:lanosterol cyclase, in the BALB/c mouse. Biochem Pharmacol. 2014 Apr 1;88(3):351-63.
Smiles	O=C(C1=CC=C(Br)C=C1)C2=CC=C(OCCCCCCN(C)CC=C)C=C2F.O=C(O)/C=C/C(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	189197-69-1
Available
Product Description	Ro 48-8071 fumarate is an inhibitor of OSC (Oxidosqualene cyclase) with IC50 of appr 6.5 nM.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	564.44
Clinical Information	No Development Reported
Solubility	DMSO : ≥ 55 mg/mL\|H2O : 100 mg/mL (ultrasonic)
Pathway	Others
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-18630A-10mg-safety-datasheet.pdf