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GNE-7915 tosylate

GNE-7915 tosylate

€67.00

Excl. VAT

Item no.	HY-18163A-10mM
Manufacturer	MedChem Express
CASRN	2070015-00-6
Amount	10 mM/1 mL
Category	Neuroscience Neuroinflammation Neural Mitochondrial Function Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.69
Formula	C26H29F4N5O6S
Citations	[1]Kavanagh ME, et al. The development of CNS-active LRRK2 inhibitors using property-directed optimisation. Bioorg Med Chem Lett.?2013 Jul 1;23(13):3690-6. [2]Estrada AA, et al. Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2012 Nov 26;55(22):9416-33.
Smiles	CCNC1=NC(NC2=C(OC)C=C(C(N3CCOCC3)=O)C(F)=C2)=NC=C1C(F)(F)F.CC4=CC=C(S(=O)(O)=O)C=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2070015-00-6
Available
Product Description	GNE-7915 tosylate is a potent, selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 9 nM.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
Molecular Weight	615.60
Clinical Information	No Development Reported
Solubility	DMSO : ≥ 50 mg/mL
Pathway	Autophagy
Manufacturers Product type	Reference compound

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HY-18163A-10mM-safety-datasheet.pdf