ML-323

€206.00

Excl. VAT

Item no.	HY-17543-50mg
Manufacturer	MedChem Express
CASRN	1572414-83-5
Amount	50 mg
Category	Oncology Neuroscience Neural Lineage Markers Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Bladder Cancer Bone Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.95
Formula	C23H24N6
Citations	[1]Liang Q, et al. A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat Chem Biol. 2014 Apr;10(4):298-304. [2]Dexheimer TS, et al. Discovery of ML323 as a Novel Inhibitor of the USP1/UAF1 Deubiquitinase Complex. National Center for Biotechnology Information; 2010-2012 Oct 23.
Smiles	CC1=CN=C(C2=C(C(C)C)C=CC=C2)N=C1NCC3=CC=C(N4N=NC=C4)C=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1572414-83-5
Available
Product Description	ML-323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay. The measured inhibition constants of ML-323 for the free enzyme (Ki) is 68 nM.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	384.48
Clinical Information	No Development Reported
Solubility	DMSO : ≥ 49 mg/mL
Pathway	Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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HY-17543-50mg-safety-datasheet.pdf