RO8994

€131.00

Excl. VAT

Item no.	HY-16999-10mM
Manufacturer	MedChem Express
CASRN	1309684-94-3
Amount	10 mM/1 mL
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Bladder Cancer Bone Cancer
Type	Inhibitors
Specific against	other
Purity	99.54
Formula	C31H31Cl2FN4O4
Citations	[1]Zhang Z, et al. Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy. Bioorg Med Chem. 2014 Aug 1;22(15):4001-4009.
Smiles	O=C([C@H](N[C@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2F)[C@@]31C(NC4=C3C=CC(Cl)=C4)=O)NC5=CC=C(C(N)=O)C=C5OC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1309684-94-3
Available
Product Description	RO8994 is a highly potent and selective MDM2 inhibitor with IC50 of nM (HTRF binding assay) and 20 nM (MTT proliferation assay).
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	613.51
Clinical Information	No Development Reported
Solubility	DMSO : ≥ 45 mg/mL
Pathway	Apoptosis; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-16999-10mM-safety-datasheet.pdf