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JH-II-127

JH-II-127

€779.00

Excl. VAT

Item no.	HY-16936-50mg
Manufacturer	MedChem Express
CASRN	1700693-08-8
Amount	50 mg
Category	Neuroscience Neuroinflammation Neural Mitochondrial Function Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.02
Formula	C19H21ClN6O3
Citations	[1]Hatcher JM, et al. Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor. ACS Med Chem Lett. 2015 Apr 7;6(5):584-9.
Smiles	O=C(C1=CC=C(NC2=NC3=NC=C(Cl)C3=C(NC)N2)C(OC)=C1)N4CCOCC4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1700693-08-8
Available
Product Description	JH-II-127 is an orally active, highly potent, selective and brain-permeable LRRK2 inhibitor, with IC50s of 6, 2 and 48 nM for wild-type LRRK2 and LRRK2-G2019S and mutant LRRK2-A2016T. JH-II-127 inhibits Ser935 phosphorylation in all tissues of mice, including the brain. JH-II-127 can be used in the study of parkinson's syndrome[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
Molecular Weight	416.86
Clinical Information	No Development Reported
Solubility	DMSO : 110 mg/mL (ultrasonic)
Pathway	Autophagy
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-16936-50mg-safety-datasheet.pdf