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Eleclazine hydrochloride

Eleclazine hydrochloride

€2,115.00

Excl. VAT

Item no.	HY-16738A-100mg
Manufacturer	MedChem Express
CASRN	1448754-43-5
Amount	100 mg
Category	Neuroscience Neural Lineage Markers Targets for Rodent Neurosciences Inhibitors & Compound Libraries Small Molecules Oligodendrocyte Markers
Type	Inhibitors
Purity	99.62
Formula	C21H17ClF3N3O3
Citations	Am J Transl Res. 2020 Jul 15;12(7):3822-3841. Philos Trans R Soc Lond B Biol Sci. 2023 Jun 19;378(1879):20220163. [1]Rajamani S et al. The novel late Na+ current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations. Br J Pharmacol. 2016 Jul 23. [2]Bacic D, et al. Eleclazine, an inhibitor of the cardiac late sodium current, is superior to flecainide in suppressing catecholamine-induced ventricular tachycardia and T-wave alternans in an intact porcine model. Heart Rhythm. 2017 Mar;14(3):448-454. [3]Potet F, Egecioglu DE, Burridge PW, George AL Jr. GS-967 and Eleclazine Block Sodium Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Mol Pharmacol. 2020 Nov;98(5):540-547.
Smiles	O=C1N(CC2=NC=CC=N2)CCOC3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C13.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	GS 6615 hydrochloride
Available
Product Description	Eleclazine (GS 6615) hydrochloride is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC50 value of <1 μM and approximately 14.2 μM, respectively. Eleclazine hydrochloride shows concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in porcine model. Eleclazine hydrochloride can be used to research cardiac arrhythmias[1][2][3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Molecular Weight	451.83
Clinical Information	Phase 3
Solubility	DMSO : 50 mg/mL (ultrasonic)
Pathway	Membrane Transporter/Ion Channel
Manufacturers Product type	Reference compound

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HY-16738A-100mg-safety-datasheet.pdf