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AGN 194310

AGN 194310

€1,712.00

Excl. VAT

Item no.	HY-16681-25mg
Manufacturer	MedChem Express
CASRN	229961-45-9
Amount	25 mg
Category	Oncology Neuroscience Neural Lineage Markers Aging & Neurological Disorders Inhibitors & Compound Libraries Small Molecules By Organ Testicular & Prostate Cancer Bone Cancer
Type	Inhibitors
Specific against	other
Purity	98.01
Formula	C28H24O2S
Citations	[1]Johnson AT, et al. Synthesis and biological activity of high-affinity retinoic acid receptor antagonists. Bioorg Med Chem. 1999 Jul;7(7):1321-38. [2]Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62. [3]Walkley CR, et al. Retinoic acid receptor antagonism in vivo expands the numbers of precursor cells during granulopoiesis. Leukemia. 2002 Sep;16(9):1763-72.
Smiles	CC(S1)(C)C=C(C2=CC=C(CC)C=C2)C3=C1C=CC(C#CC4=CC=C(C(O)=O)C=C4)=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	VTP-194310
Available
Product Description	AGN 194310 (VTP-194310) is a high affinity, potent and selective retinioic acid receptors (RARs) pan-antagonist with Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2]. AGN 194310 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	424.55
Clinical Information	No Development Reported
Solubility	DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : 1 mg/mL (ultrasonic)
Pathway	Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Reference compound

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HY-16681-25mg-safety-datasheet.pdf