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Phenformin hydrochloride

Phenformin hydrochloride

€38.00

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Item no.	HY-16397A-10mM
Manufacturer	MedChem Express
CASRN	834-28-6
Amount	10 mM/1 mL
Category	Oncology Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.29
Formula	C10H16ClN5
Citations	[1]Sakamoto K, et al. Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR. Am J Physiol Endocrinol Metab.?2004 Aug;287(2):E310-7. [2]Moreira AL, et al. Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation. J Exp Med. 1993 Jun 1;177(6):1675-80. [3]Woollhead AM, et al. Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells. J Physiol. 2005 Aug 1;566(Pt 3):781-92. Epub 2005 [4]Dilman VM, et al. Inhibition of DMBA-induced carcinogenesis by phenformin in the mammary gland of rats. Arch Geschwulstforsch. 1978;48(1):1-8. [5]Zhang L, et al. Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H457-66.
Smiles	NC(NC(NCCC1=CC=CC=C1)=N)=N.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Phenethylbiguanide hydrochloride
Available
Product Description	Phenformin hydrochloride is an anti-diabetic agent from the biguanide class, can activate AMPK activity.
StorageTemperature	4°C (Powder, stored under nitrogen)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	241.72
Clinical Information	Launched
Solubility	DMF : 1 mg/mL (ultrasonic)\|DMSO : 1 mg/mL (ultrasonic; adjust pH to 2 with 1M HCl)\|Ethanol : 2 mg/mL (ultrasonic)\|H2O : 12.5 mg/mL (ultrasonic)
Isoform	AMPK
Pathway	Autophagy; Epigenetics; PI3K/Akt/mTOR
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-16397A-10mM-safety-datasheet.pdf