BQ-788

€413.00

Excl. VAT

Item no.	HY-15894A-5mg
Manufacturer	MedChem Express
CASRN	173326-37-9
Amount	5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Brain Cancer Nervous System Cancer
Type	Inhibitors
Purity	98.28
Formula	C34H51N5O7
Citations	Cells. 2021, 10(11), 3072. Environ Pollut. 2016 Feb;209:11-20. Environ Pollut. 2016 Nov;218:487-496. Neurotherapeutics. 2021 Oct 18. Toxicol Sci. 2016 Jan;149(1):213-26. BMC Cancer. 2018 Feb 6;18(1):154. Environ Sci Pollut Res Int. 2018 May;25(15):14713-14725. PLoS Pathog. 2020 Oct 19;16(10):e1008947. [1]Fattori V, et al. Differential regulation of oxidative stress and cytokine production by endothelin ETA and ETB receptors in superoxide anion-induced inflammation and pain in mice. J Drug Target. 2016 Oct 5:1-27 [2]Okada M, et al. BQ-788, a selective endothelin ET(B) receptor antagonist. Cardiovasc Drug Rev. 2002 Winter;20(1):53-66. [3]Sargent CA, et al. Effect of endothelin antagonists with or without BQ 788 on ET-1 responses in pithed rats. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S216-8.
Smiles	CCCC[C@H](C(O)=O)NC([C@@H](CC1=CN(C(OC)=O)C2=CC=CC=C12)NC([C@H](CC(C)(C)C)NC(N3[C@H](C)CCC[C@@H]3C)=O)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	173326-37-9
Available
Product Description	BQ-788 is a potent, selective ETB receptor antagonist with IC50 of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC cells with IC50 of 1300 nM[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-sugar/lipid metabolism
Molecular Weight	641.80
Clinical Information	Phase 1
Solubility	DMSO : 170 mg/mL (ultrasonic; warming; heat to 60°C)
Isoform	ETB
Pathway	GPCR/G Protein
Manufacturers Product type	Reference compound

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Amount: 5 mg

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