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GGTI298 Trifluoroacetate

GGTI298 Trifluoroacetate

€595.00

Excl. VAT

Item no.	HY-15871-25mg
Manufacturer	MedChem Express
CASRN	1217457-86-7
Amount	25 mg
Category	Food Safety Allergenes Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Purity	99.87
Formula	C29H34F3N3O5S
Citations	J Oral Biosci. 2023 Aug 23;S1349-0079(23)00122-6. Mol Cell Proteomics. 2023 Jun 14;100593. Int Immunopharmacol. 2023 Mar 15;117:110014. [1]McGuire TF, et al. Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation. J Biol Chem. 1996 Nov 1;271(44):27402-7. [2]Sheikh IA, et al. The Epac1 signaling pathway regulates Cl- secretion via modulation of apical KCNN4c channels in diarrhea. J Biol Chem. 2013 Jul 12;288(28):20404-15. [3]Chen S, et al. Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis. Mol Cancer. 2010 Jan 29;9:23.
Smiles	CC(C)C[C@@H](C(OC)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=C3C=CC=CC3=CC=C2)=O.O=C(O)C(F)(F)F
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1217457-86-7
Available
Product Description	GGTI298 Trifluoroacetate is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, which can inhibit Rap1A with IC50 of 3 μM; little effect on Ha-Ras with IC50 of >20 μM.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	593.66
Clinical Information	No Development Reported
Solubility	DMSO : 100 mg/mL (ultrasonic)
Pathway	Apoptosis; GPCR/G Protein; MAPK/ERK Pathway
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-15871-25mg-safety-datasheet.pdf