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GNE0877

GNE0877

€129.00

Excl. VAT

Item no.	HY-15796-10mM
Manufacturer	MedChem Express
CASRN	1374828-69-9
Amount	10 mM/1 mL
Category	Neuroscience Neuroinflammation Neural Mitochondrial Function Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.15
Formula	C14H16F3N7
Citations	[1]Estrada AA, et al. Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2014 Feb 13;57(3):921-36.
Smiles	CC1=NN(C(C)(C)C#N)C=C1NC2=NC=C(C(F)(F)F)C(NC)=N2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1374828-69-9
Available
Product Description	GNE0877 is a highly selective, orally active and brain-penetrant LRRK2 inhibitor with an IC50 of 3 nM and a Ki of 0.7 nM. GNE0877 can be used for the research of neuroscience[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
Molecular Weight	339.32
Clinical Information	No Development Reported
Solubility	DMSO : 250 mg/mL (ultrasonic)
Pathway	Autophagy
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-15796-10mM-safety-datasheet.pdf