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AMG 487

AMG 487

€1,157.00

Excl. VAT

Item no.	HY-15319-100mg
Manufacturer	MedChem Express
CASRN	473719-41-4
Amount	100 mg
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Stem Cell Markers
Type	Inhibitors
Specific against	other
Purity	99.65
Formula	C32H28F3N5O4
Citations	[1]Walser TC, et al. Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer. Cancer Res. 2006 Aug 1;66(15):7701-7. [2]Johnson M, et al. Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3339-43. [3]Cambien B, et al. Organ-specific inhibition of metastatic colon carcinoma by CXCR3 antagonism. Br J Cancer. 2009 Jun 2;100(11):1755-64.
Smiles	O=C(N([C@@H](C1=NC2=NC=CC=C2C(N1C3=CC=C(OCC)C=C3)=O)C)CC4=CC=CN=C4)CC5=CC=C(OC(F)(F)F)C=C5
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	473719-41-4
Available
Product Description	AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	603.59
Clinical Information	No Development Reported
Solubility	DMSO : ≥ 41 mg/mL
Isoform	CXCR3
Pathway	GPCR/G Protein; Immunology/Inflammation
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-15319-100mg-safety-datasheet.pdf