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EPZ004777

EPZ004777

€93.00

Excl. VAT

Item no.	HY-15227-5mg
Manufacturer	MedChem Express
CASRN	1338466-77-5
Amount	5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Bone Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	98.78
Formula	C28H41N7O4
Citations	[1]Daigle SR, et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell. 2011 Jul 12;20(1):53-65. [2]Chen L, et al. Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l. Leukemia. 2013 Apr;27(4):813-22.
Smiles	NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CN(C(C)C)CCCNC(NC4=CC=C(C(C)(C)C)C=C4)=O)O3)C=C2)=NC=N1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1338466-77-5
Available
Product Description	EPZ004777 is a potent, selective DOT1L inhibitor with an IC50 of 0.4 nM.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	539.67
Clinical Information	No Development Reported
Solubility	DMSO : 80 mg/mL (ultrasonic)
Isoform	DOT1L
Pathway	Apoptosis; Epigenetics
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-15227-5mg-safety-datasheet.pdf