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PCI-34051

PCI-34051

€118.00

Excl. VAT

Item no.	HY-15224-10mg
Manufacturer	MedChem Express
CASRN	950762-95-5
Amount	10 mg
Category	Food Safety Drugs Neuroscience Aging & Neurological Disorders Neural Epigenetics Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.69
Formula	C17H16N2O3
Citations	[1]Balasubramanian S, et al. A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas. Leukemia. 2008 May;22(5):1026-34. [2]Ren Y, et al. Therapeutic effects of histone deacetylase inhibitors in a murine asthma model. Inflamm Res. 2016 Dec;65(12):995-1008.
Smiles	COC(C=C1)=CC=C1CN2C3=CC(C(NO)=O)=CC=C3C=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	950762-95-5
Available
Product Description	PCI-34051 is a potent and selective HDAC8 inhibitor with IC50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	296.32
Clinical Information	No Development Reported
Solubility	DMSO : ≥ 30 mg/mL
Isoform	HDAC1; HDAC10; HDAC6; HDAC8
Pathway	Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-15224-10mg-safety-datasheet.pdf