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Glibenclamide

Glibenclamide

Item no.	HY-15206-1g
Manufacturer	MedChem Express
CASRN	10238-21-8
Amount	1 g
Category	Oncology Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Cardiovascular Research Ischemia & Reperfusion Injury Hypertension Inhibitors & Compound Libraries Small Molecules Arrhythmias By Organ Skin Cancer
Type	Inhibitors
Purity	99.70
Formula	C23H28ClN3O5S
Citations	[1]Fernandes MA, et al. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability. J Biochem Mol Toxicol. 2004;18(3):162-169. [2]Heo R, et al. The anti-diabetic drug trelagliptin induces vasodilation via activation of Kv channels and SERCA pumps. Life Sci. 2021;283:119868. [3]Qiu Y, et al. Glyburide Regulates UCP1 Expression in Adipocytes Independent of KATP Channel Blockade. iScience. 2020;23(9):101446. [4]Golstein PE, et al. P-glycoprotein inhibition by glibenclamide and related compounds. Pflugers Arch. 1999;437(5):652-660. [5]Zhou J, et al. Glibenclamide-Induced Autophagy Inhibits Its Insulin Secretion-Improving Function in β Cells. Int J Endocrinol. 2019;2019:1265175.
Smiles	ClC1=CC(C(NCCC2=CC=C(S(NC(NC3CCCCC3)=O)(=O)=O)C=C2)=O)=C(OC)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Glyburide
Available
Product Description	Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-protein/nucleotide metabolism
Molecular Weight	494.00
Clinical Information	Launched
Solubility	DMSO : 250 mg/mL (ultrasonic)\|H2O : 0.1 mg/mL (ultrasonic; warming)
Pathway	Autophagy; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-15206-1g-safety-datasheet.pdf