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NSC 74859

NSC 74859

€76.00

Excl. VAT

Item no.	HY-15146-10mg
Manufacturer	MedChem Express
CASRN	501919-59-1
Amount	10 mg
Category	Oncology Neuroscience Neural Lineage Markers Metabolism Diabetes Neural Transcription Factors Molecular Targets for Neuroscience Targets for Rodent Neurosciences Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Breast Cancer Hepatic Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	98.64
Formula	C16H15NO7S
Citations	[1]Siddiquee K, et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7391-6. [2]Zhou C, et al. STAT3 upregulation in pituitary somatotroph adenomas induces hypersecretion. J Clin Invest. 2015 Apr;125(4):1692-702 [3]Lin L, et al. The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling. Oncogene. 2009 Feb 19;28(7):961-72.
Smiles	OC1=CC(NC(COS(=O)(C2=CC=C(C=C2)C)=O)=O)=CC=C1C(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	S3I-201
Available
Product Description	NSC 74859 (S3I-201) is a selective Stat3 inhibitor with an IC50 of 86 μM[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	365.36
Clinical Information	No Development Reported
Solubility	DMSO : 100 mg/mL (ultrasonic)
Isoform	STAT3
Pathway	JAK/STAT Signaling; Stem Cell/Wnt
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-15146-10mg-safety-datasheet.pdf