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Cevipabulin

Cevipabulin

€1,122.00

Excl. VAT

Item no.	HY-14949-100mg
Manufacturer	MedChem Express
CASRN	849550-05-6
Amount	100 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Brain Cancer
Type	Inhibitors
Purity	98.0
Formula	C18H18ClF5N6O
Citations	[1]Beyer CF, et al. TTI-237: a novel microtubule-active compound with in vivo antitumor activity. Cancer Res. 2008 Apr 1;68(7):2292-300. [2]Beyer CF, et al. The microtubule-active antitumor compound TTI-237 has both paclitaxel-like and vincristine-like properties. Cancer Chemother Pharmacol. 2009 Sep;64(4):681-9.
Smiles	C[C@@]([H])(C(F)(F)F)NC1=C(C2=C(F)C=C(OCCCNC)C=C2F)C(Cl)=NC3=NC=NN13
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	TTI-237
Available
Product Description	Cevipabulin (TTI-237) is an oral, microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line[1][2].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	464.82
Clinical Information	Phase 1
Solubility	DMSO : 16.67 mg/mL (ultrasonic)
Pathway	Cell Cycle/DNA Damage; Cytoskeleton
Manufacturers Product type	Reference compound

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HY-14949-100mg-safety-datasheet.pdf