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Fluvastatin

Fluvastatin

€133.00

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Item no.	HY-14664-50mg
Manufacturer	MedChem Express
CASRN	93957-54-1
Amount	50 mg
Category	Oncology Metabolism Cholesterol & Lipid Metabolism Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Testicular & Prostate Cancer Hepatic Cancer
Type	Inhibitors
Specific against	other
Purity	95.0
Formula	C24H26FNO4
Citations	Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868. Cell Prolif. 2021 Jan;54(1):e12953. Chem Eng J. 1 January 2023, 138972. Front Cell Dev Biol. 2020 May 28;8:404. Front Oncol. 10 May 2021. Front Oncol. 2021 May 10;11:595285. Pharmacol Res. 2023 Mar 10;106724. Proteomics. 2023 May 4;e2300041. Front Bioeng Biotechnol. 2022 Mar 17;10:826093. Mol Med Rep. 2018 Mar;17(3):3944-3950. Pathogens. 2021, 10(3), 283. [1]Makabe S, et al. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. Atherosclerosis. 2010 Dec;213(2):377-84. [2]Wu Zhang, et al. Fluvastatin, a lipophilic statin, induces apoptosis in human hepatocellular carcinoma cells through mitochondria-operated pathway. Indian J Exp Biol. 2010 Dec;48(12):1167-74.
Smiles	O=C(O)C[C@H](O)C[C@H](O)/C=C/C(N1C(C)C)=C(C2=CC=C(F)C=C2)C3=C1C=CC=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	XU 62-320 (free acid)
Available
Product Description	Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1][2][3].
StorageTemperature	-20°C (Powder, stored under nitrogen)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	411.47
Clinical Information	Launched
Solubility	DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Pathway	Autophagy; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 mg

Listprice: €133.00

Price: €133.00

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