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Donepezil

Donepezil

€59.00

Excl. VAT

Item no.	HY-14566-10mg
Manufacturer	MedChem Express
CASRN	120014-06-4
Amount	10 mg
Category	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Inhibitors & Compound Libraries Small Molecules By Organ Brain Cancer Nervous System Cancer
Type	Inhibitors
Purity	99.91
Formula	C24H29NO3
Citations	Comput Struct Biotec. 2023 Feb 24. Eur J Med Chem. 2023 Dec 21, 116071. Foods. 2022, 11(14), 2095. Journal of Pharmaceutical Investigation. 2021 Mar 31. Clin Transl Med. 2021 May 28. J Integr Neurosci. 2023 May 16, 22(3), 76. Patent. US20210378961A1. [1]Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22(8): p. 609-13. [2]Snape, M.F., et al., A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology, 1999. 38(1): p. 181-93. [3]Huang, Z.H., et al., Donepezil protects endothelial cells against hydrogen peroxide-induced cell injury. CNS Neurosci Ther, 2012. 18(2): p. 185-7.
Smiles	O=C(C(C=C(OC)C(OC)=C1)=C1C2)C2CC(CC3)CCN3CC4=CC=CC=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	E2020 (free base)
Available
Product Description	Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].
StorageTemperature	4°C (Powder, sealed storage, away from moisture and light)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
Molecular Weight	379.49
Clinical Information	Launched
Solubility	DMSO : 33.33 mg/mL (ultrasonic)\|H2O : 2 mg/mL (ultrasonic; warming; heat to 80°C)
Isoform	AChE
Pathway	Neuronal Signaling
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-14566-10mg-safety-datasheet.pdf