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Quetiapine

Quetiapine

€142.00

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Item no.	HY-14544-100mg
Manufacturer	MedChem Express
CASRN	111974-69-7
Amount	100 mg
Category	Food Safety Histamines Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Purity	99.88
Formula	C21H25N3O2S
Citations	[1]Hanzhi Wang, et al. Quetiapine Inhibits Microglial Activation by Neutralizing Abnormal STIM1-Mediated Intercellular Calcium Homeostasis and Promotes Myelin Repair in a Cuprizone-Induced Mouse Model of Demyelination. Front Cell Neurosci. 2015 Dec 21;9:492. [2]Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66.
Smiles	OCCOCCN(CC1)CCN1C2=NC3=CC=CC=C3SC4=C2C=CC=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ICI204636
Available
Product Description	Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
Molecular Weight	383.51
Clinical Information	Launched
Solubility	DMSO : 100 mg/mL (ultrasonic)\|Ethanol : 100 mg/mL (ultrasonic)\|H2O : 0.1 mg/mL (ultrasonic; warming; heat to 50°C)
Isoform	5-HT1 Receptor; 5-HT2 Receptor
Pathway	GPCR/G Protein; Neuronal Signaling
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-14544-100mg-safety-datasheet.pdf