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Cimetidine

Cimetidine

€91.00

Excl. VAT

Item no.	HY-14289-5g
Manufacturer	MedChem Express
CASRN	51481-61-9
Amount	5 g
Category	Oncology Food Safety Histamines Neuroscience Neural Lineage Markers Aging & Neurological Disorders Neural Adhesion Molecules Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Lymphatic System Cancer Uterine, Ovarian & Cervical Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	98.0
Formula	C10H16N6S
Citations	[1]Takahashi, H.K., et al., Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol, 2006. 70(2): p. 450-3. [2]Sprowl, J.A., et al., Conjunctive therapy of cisplatin with the OCT2 inhibitor cimetidine: influence on antitumor efficacy and systemic clearance. Clin Pharmacol Ther, 2013. 94(5): p. 585-92. [3]Zheng, Y., et al., Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells. Mol Immunol, 2013. 54(1): p. 74-83. [4]Fukuda, M., K. Kusama, and H. Sakashita, Cimetidine inhibits salivary gland tumor cell adhesion to neural cells and induces apoptosis by blocking NCAM expression. BMC Cancer, 2008. 8: p. 376. [5]Longhini, R., et al., Cimetidine Reduces the Alveolar Bone Loss in Induced Periodontitis in Rat Molars. J Periodontol, 2013. [6]M J Smit, et al. Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6802-7.
Smiles	CC1=C(CSCC/N=C(NC)/NC#N)NC=N1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	SKF-92334
Available
Product Description	Cimetidine (SKF-92334) is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine has anti-cancer and anti-inflammatory activity[1][2][5].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	252.34
Clinical Information	Launched
Solubility	DMSO : 60 mg/mL (ultrasonic)\|H2O : 2 mg/mL (ultrasonic)
Isoform	H2 Receptor; Histamine Receptor
Pathway	Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-14289-5g-safety-datasheet.pdf